– Discussion: – a chronic progressive disease osteoblasts and osteoclasts which results in abnormal bone remodeling; – etiology, staging, and pathogenesis – prevalence: – uncommon in pts under age of 55 yrs but relatively common in later life, occurring in 3-4% of persons over 55 yrs & occurs in 10% in pts over age 80; – reference: – … Read more
– Discussion: – commonly presents in females over age 60 years of age; – pain may or may not be associated w/ acute injury and may be worse at night; – these lesions often show articular degenerative changes, especially when lesions are large or when there is pre-existing varus … Read more
– Discussion: – predisposing conditions: – open fracture (traumatic tibia infections) – sickle cell anemia – septic arthritis – in children, distinguishing between metaphyseal osteomyelitis and … Read more
– See: tibial infection and debridement of tibial fractures – Discussion: – see cierny classifcation – a sequestrum is infected dead bone resulting from osteomyelitis; – it is secluded from host immune system and is secluded from antibiotics; – result is a chronic and persistent of infection; … Read more
– Pathogenesis: – see: hematogenous osteomyelitis and pediatric bone circulation – tortuous course of the nutrient vessels in bone causes bacteria to be trapped in the metaphysis; – once lodged in the metaphysis, the infection spreads toward the epiphysis; – in neonates the periosteum … Read more
(see also: Pyknodyostosis) Discussion disease characterized by failure of maturation and organization of collagen fibers; defect in collagen (procollagen to type I collagen sequence and abnormal cross linking) leading to decreased collagen secretion, bone fragility; there may be an inability to form normal bone due to a defect in osteoblastic function; with the formation of … Read more
– Discussion: – see: homeobox genes database – history: discovered by Marshall Urist in the early 1960s; – currently sixteen different proteins (BMP-1 through BMP-16) have been identified; – these proteins can now be produced by recombinant DNA technology and are further purified by column chromatography; … Read more
– Discussion: – a developmental dysplasia of peripheral growth plate which forms a cartilage capped projection of bone found near metaphyses of long bones; – peripheral chondroblast grows outward from the metaphysis, acting as an ectopic growth plate, which ceases growth at skeletal maturation; … Read more
– See: Pediatric Elbow Injuries – Discussion: – a traction apophysisitis of the medial epicondyle which needs to be distinguished from avulsion frx of the medial epicondyle – the medial epicondyle is an apophysis which is connected to the MCL as well as being connected to the flexor-pronator mass; – both of these structures will … Read more