– Discussion: – a chronic progressive disease osteoblasts and osteoclasts which results in abnormal bone remodeling; – etiology, staging, and pathogenesis – prevalence: – uncommon in pts under age of 55 yrs but relatively common in later life, occurring in 3-4% of persons over 55 yrs & occurs in 10% in pts over age 80; – reference: – … Read more
It is estimated that as many as 40 million Americans or 1 in 7 people have some form of arthritic disease. It has been reported that arthritis is the number one cause of disability in America, limiting the everyday activities for approximately seven million individuals. The efforts of medical … Read more
– Discussion: – osteopetrosis is failure of osteoclastic and chondroclastic resorption; – bones become exceedingly dense; – marrow space is filled w/ unresorbed dense bone; – disease results from lack of osteoclastic resorption, leading to thickened bones & exclusion of marrow cavity; – there is absence of marrow elements & these patients are susceptible to … Read more
– Discussion: – most common metabolic bone dz; – definition: – what appears to be a characteristic of osteoporosis is an uncoupling of the osteoblastic and osteoclastic processes; – WHO definition: a bone mineral density that is 2.5 SD below the mean peak value … Read more
– Discussion: – predisposing conditions: – open fracture (traumatic tibia infections) – sickle cell anemia – septic arthritis – in children, distinguishing between metaphyseal osteomyelitis and … Read more
– Pathogenesis: – osteomyelitis occurs most frequently in the long bones of lower extremities, & to a lesser extent the upper extremities; – hematogenous osteomyelitis – pediatric bone circulation: tortuous course of nutrient vessels in bone causes bacteria to be trapped in the metaphysis; – epiphyseal plate prevents infection from entering the … Read more
– Pathogenesis: – see: hematogenous osteomyelitis and pediatric bone circulation – tortuous course of the nutrient vessels in bone causes bacteria to be trapped in the metaphysis; – once lodged in the metaphysis, the infection spreads toward the epiphysis; – in neonates the periosteum … Read more
– See: – osteoblasts – osteocytes – Discussion: – osteoclast is a large multinucleated cell that plays an active role in bone resorption; – monocytes from the marrow or the blood serve as precursors of osteoclasts; – osteoclasts are found in notches or … Read more
(see also: Pyknodyostosis) Discussion disease characterized by failure of maturation and organization of collagen fibers; defect in collagen (procollagen to type I collagen sequence and abnormal cross linking) leading to decreased collagen secretion, bone fragility; there may be an inability to form normal bone due to a defect in osteoblastic function; with the formation of … Read more
– See: Bone Tumor Menu – Discussion: – benign osseous tumor usually less than 1.5 cm in diameter, comprising 11% of all benign bone tumors; – no cases of malignant transformation has been reported; – occurs primarily in adolescents and less often in children; … Read more