Data Trace Editor
Histology of Ewing’s Sarcoma
– Discussion: – small, round, neoplastic cells w/ large oval hyperchromatic nuclei; – vague indistinct (scant) cytoplasm & cytoplasmic membrane; – cells are usually spread out in thick sheets; – mitoses are common, and pseudorosette patterns are typical. – high cellularity, little intracellular stroma; … Read more
Histology of Chondrosarcoma
– See: – Bone Tumor Menu
Histology of Chondroblastoma
– Discussion: – shows characteristic “cobblestone” pattern; – areas of round, plump chondroblasts (stones), enmeshed in chondroid matrix; – nodular areas of a chondroid tissue are prominent; – cartilagenous matrix may have small foci of calcification between between chondroblasts (chicken wire calcification) around islands of cartilage; … Read more
Histology and Growth of Bone
Microscopic Structure of Bone Cancellous Bone Circumferential Grouth Haversian System Longitudinal Growth Development of Bone from a Cartilage Model Tubulation
Histological Features of Myopathy
– Discussion: – individual fibers are affected in random fashion throughout the muscle; – muscle fibers become rounded, will vary in size; – nuclei frequently migrate centrally; – may see phagocytosis of individual cells; – unlike neuropathic disease, in myopathy, active regeneration of fibers is … Read more
Histological Features of Giant Cell Tumor of Bone
– Discussion: – numerous multinucleated giant cells, proliferative stroma, areas of necrosis, reactive peripheral bone, & occassional mitotic figures in the stroma (but no mitotic figures in the giant cells); – stromal cells appear elongate with oval nuclei; – giant cells may resemble osteoclasts; – Histologic Differential Dx: … Read more
Histological Characteristics of Aneurysmal Bone Cyst
– Discussion: – mixture of benign stromal tissue – large vascular lacunae separated by septa in which numerous giant cells are found & & filled with clotted blood (blood-filled spaces with bland fibrous connective tissue septa) that resembles cranberry sauce; – cavernous spaces vessel lack walls & … Read more
Histologic Changes in Rickets
– Medullary bone: – decreased in quantity, & trabecula are thin & irregular; – feature that most sig helps to establish the dx is presence of layer of unmineralized bone (osteoid seam) surrounding mineralized segment; – trabeculae & cortex have less bone, & is surrounded by a layer of unmineralized bone (osteoid seam) – osteoid seams; … Read more
Hip Spica Cast
– See: Pediatric Femoral Frx Menu – Discussion: – timing: – Immediate single-leg spica cast for pediatric femoral diaphysis fractures. – contraindications: – unacceptable shortening or angulation; – open fractures; – thoracic or intra-abdominal trauma; … Read more