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Histological Features of Giant Cell Tumor of Bone


- Discussion:
    - numerous multinucleated giant cells, proliferative stroma, areas of necrosis, reactive peripheral bone, & occassional mitotic figures in the 
          stroma (but no mitotic figures in the giant cells);
    - stromal cells appear elongate with oval nuclei;
    - giant cells may resemble osteoclasts;

- Histologic Differential Dx:
    - ABC, PVS, & TB will have multinucleated giant cells;
    - tuberculous giant cells (Langhans) has peripherally located nuclei


Giant-cell reparative granuloma of the hand and foot bones.