Ortho Oracle - orthopaedic operative atlas

Microscopic features of the Meniscus

– Discussion:     – meniscal cells while typical chondrocytes, are called fibrochondrocytes because they synthesize fibrocartilage matrix, rather than hyaline               cartilage matrix typical of articular cartilage;     – menisci are composed of circumferentially oriented collagen fibers, which are parallel to its peripheral border;     – orientation of type I collagen fiber bundles is the major determinant … Read more

Mid Palmar Space

– Discussion:     – extends lateromedially from mid-palmar septum to hypothenar eminence;     – extends proximodistally to level of superficial palmar arch;     – dorsally the bursa is bordered by the middle, ring, (and ? little) finger metacarpals and palmarly by the flexor tenons and lumbricals;     – bursa functions to … Read more

Methylprednisolone / Medrol / Solumedrol

– See Steroids  – Discussion: – not used for Cerebral edema;  – useful for Potassium wasting;  – Dosing:  – PO: 4-48mg/day depending on disease and clinical response;   – IV: 30mg/kg infused over 10-20min for septic shock;  – Dosage for Severe bronchospasm:  – 0.5-1mg/kg initially, followed by tapering doses q4-6hr  Original Articles: A Randomized, Controlled Trial … Read more

Metoclopramide/Reglan/ Clopra

– Diabetic Gastroparesis:   – 10mg PO 30min AC and HS for2-8 weeks prn;   – GI Reflux:  – 10-15mg PO 30min AC and HS; maximum duration of therapy is 12 weeks;  – Prophylaxis of N/V in Cancer Chemotherapy;  – IV infusion 1-2mg/kg diluted in 0.9% saline and given slowly (over 15min) 30 min before … Read more

METOLAZONE/ZAROXOLYN

– Discussion:  – mild to moderate essential HTN:  – edema of renal dz or cardiac failure, to potentiate effects of loop Diuretics;  – inhibits NaCl resorption in corical diluting segment and in proximal tubule; HTN:2.5-5mg PO qd;  – Edema: 5-20mg PO qd;  – CHF: 5-10mg qd;  – Potentiation of loops:2.5-10mg-titrated to effect;  – Precautions:  – Monitor … Read more

Metoprolol/Lopressor

– See: Class II Agents – Discussion:     – for HTN, MI, angina pectoris; beta blocking agent;     – HTN dose:              – 100mg PO qd in single or divided doses; may increase dosage q1-2 weeks until desired response;              – usual range … Read more

Metronidazole / Flagyl

– Discussion and Dosage:     – type of reducing compound that leads to the formation of oxygen free radicals which are toxic to anaerobic bacteria;     – for amebiasis, trichomoniasis, B.fragilis, C. difficile;     – is effective for B.fragilis which is resistant to clindamycin, chloramphenicol, penicillin G;     – amebic: 750mg … Read more

Mezlocillin/Mezlin

– See:        – Penicillin Family        – AntiPseudo – Adult: 2-4gm q4-6hr Injection; or 200-300 mg/kg/24hr; 1.85mEq Na/gm; – More active than Ticarcillin against Enterobacteriacae, same activity against P.aeruginosa;  good activity against B.fragilis; – Diffusion from blood into CSF adequate w/ or w/o Inflammation; Ratio of CSF to Blood Level … Read more

Miconazole/Monistat

– For severe fungal infections including coccidioidomycosis, candidiasis, Cryptococcus, and others; various tinea forms; cutaneous candidiasis; vulvovaginal candidiasis; tinea versicolor; – Adult: systemic: dosage range from 200-3,600 mg/24hr IV based on diagnosis; to be administered diluted to minimum volume of 200 ml NSS; – Topical apply to affected area twice daily for 2-4 weeks; – … Read more

METHYLDOPA/ALDOMET

– for essential hypertension;  – Adult Dosing:  – 250-500mg PO bid/tid (max: 2-3gm/day) or 250mg-1gm IV q4-8hr; – Precautions:  – sudden withdrawl may result in significant rebound HTN; – do not use in presence of liver disease;  – use smaller doses in renal failure