- Discussion: 
- mild to moderate essential HTN: 
- edema of renal dz or cardiac failure, to potentiate effects of loop Diuretics; 
- inhibits NaCl resorption in corical diluting segment and in proximal tubule; HTN:2.5-5mg PO qd; 
- Edema: 5-20mg PO qd; 
- CHF: 5-10mg qd; 
- Potentiation of loops:2.5-10mg-titrated to effect; 
- Precautions: 
- Monitor fluid and electrolytes 2-10 mg qd will potentiate loop diruetics;

- Contraindicated w/ Anuria, hepatic coma or precoma; 
- Use caution when administering metolazone to hyperuricemia patients, patiets with severly impaired renal function, diabetics