- Discussion:
- osteoclasts are found in most of bone tumors, or at least there are multinucleated cells that look like osteoclasts;
- there cells are quite striking in appearance;
- host bone involved by a tumor reacts to it in a very limited manner;
- it may undergo Resorption, which roentgenographically appears as lytic or osteoporotic area;
- resorption is accomplished by osteoclasts that may be so abundant as to appear to be integral part of lesion rather than reaction to it;
- host bone may respond to the presence of tumor by forming more bone;
- this response is seen in the osteoblastic reaction to metastatic cancer of prostate;
- its important to determine whether the bone formed in tumor is being produced by the actual tumor cells or by normal osteoblasts reacting
to the tumor;
- though there are several benign tumors which actually form bone, there is only one malignant bone-forming tumor, osteogenic sarcoma;
- in most situations, the host bone responds to a tumor by combination of resorption and bone formation