Data Trace Editor – References: – testosterone / estrogen: Testosterone levels increase in association with recovery from acute fracture in men. Evaluating the affect and reversibility of opioid-induced androgen deficiency in an orthopaedic animal fracture model. Testosterone delivered with a scaffold is as effective as BMP in promoting the repair of defect of femoral … Read more
Discussion is a type of metabolic bone disease in which the essential problem is a lack of available calcium or phosphorus (or both) for mineralization of newly formed osteoid; children w/ rickets & adults w/ osteomalacia present w/ similar findings; etiology of rickets and osteomalacia hyperthyroid induced osteopenia: chronic use of anticonvulsant medication: deficiency states: … Read more
– Discussion: – rickets or osteomalacia may occur from most anticonvulsants; – disorder is common and may be present in upto 15% of pts; – syndrome is dangerous because of increased sensitivity of central nervous system that occurs with lowering of serum Ca concentration; – disorder can be corrected by administration of 1,25-dihydroxyvitamin D
– See: – osteoblasts – osteocytes – Discussion: – osteoclast is a large multinucleated cell that plays an active role in bone resorption; – monocytes from the marrow or the blood serve as precursors of osteoclasts; – osteoclasts are found in notches or … Read more
– See: – osteoblasts and osteoclasts – Discussion: – osteocyte is mentioned as possibly having resorptive capabilities; – it is the most numerous type of bone cell and is derived from an osteoblasts that is not longer synthesizing collagen; – osteocytes were once considered to be dormant, metabolically inactive … Read more
(see also: Pyknodyostosis) Discussion disease characterized by failure of maturation and organization of collagen fibers; defect in collagen (procollagen to type I collagen sequence and abnormal cross linking) leading to decreased collagen secretion, bone fragility; there may be an inability to form normal bone due to a defect in osteoblastic function; with the formation of … Read more
– Discussion: – see: homeobox genes database – history: discovered by Marshall Urist in the early 1960s; – currently sixteen different proteins (BMP-1 through BMP-16) have been identified; – these proteins can now be produced by recombinant DNA technology and are further purified by column chromatography; … Read more
– See: Bone Tumor Menu – Discussion: – benign osseous tumor usually less than 1.5 cm in diameter, comprising 11% of all benign bone tumors; – no cases of malignant transformation has been reported; – occurs primarily in adolescents and less often in children; … Read more
– Discussion: – a developmental dysplasia of peripheral growth plate which forms a cartilage capped projection of bone found near metaphyses of long bones; – peripheral chondroblast grows outward from the metaphysis, acting as an ectopic growth plate, which ceases growth at skeletal maturation; … Read more