– antipyschotic med, for chronic pyschotic patients who are resistant to usual medications; Both active and passive symptoms may improve with this medication; – Side effects include Agranulocytosis in 1-2% of patients; – WBC < 3000 or ANC < 1500 calls for interuption of treatment; – Also note dose related increase risk of seizures; – … Read more
– See: Transdermal * For HTN, opioid & tobacco withdrawl; – Central alpha adrenergic receptor agonist; * Adult: 0.05-0.10 mg PO bid-qid adjusted daily by 0.1-0.2 mg increments – initial oral doses of 0.1 mg are given twice daily and adjusted to usual maintenance dose of 0.2 to 0.8 mg/day; – maximum recommended oral doses … Read more
– for acute anxiety, ETOH w/drawl; Benzodiazepine; – Adult:individualized: 15-60mg/day PO in single or divideddoses; – Monitor patients with renal and hepatic impairment since drug may accumulate; CNS depressant effects; may be habit forming; – Contraindicated with acute narrow angle glaucoma, depressive neuroses, psychotic reactions; Caution with renal or hepatic failure; Caution w/ concomitant use … Read more
– Discussion: – for serious infections with Gram Neg anaerobes (B. fragilis) or staph / streptococcus infections in patients allergic to penicillin; – not good for gm neg aerobes; – clindamycin binds exclusively to the 50 S subunit of bacterial ribosomes and suppresses protein synthesis; (bacterostatic not bacterocidal); … Read more
– See: – Bone Tumor Menu and Osteosarcoma Demonstration Project – Discussion: – malignant tumor of bone in which neoplastic osteoid is produced by a proliferating spindle cell stroma; – most common primary malignant bone tumor of mesenchymal derivation; – arises in adolescents, and second or third decade; – … Read more
– for PUD, prophylaxis in trauma, burns, surgery; – Adult: active PUD: 300 mg PO/IV tid-qid, or 400 mg PO bid; – over 90% of ulcers should heal after 12 wks of therapy – Hosp Prac. 1979 – ulcers which have not healed after 12 wks, probably will not heal w/ H2 Blockers; – for … Read more
– See: Bone Tumor Menu – Discussion: – malignant cartilaginous tumor of bone (3rd most common malignant bone tumor / comprises 20% of malignant bone lesions); – it is less common and less aggressive than osteosarcoma; – staging: – histologic grading is best predictor of stage; – most often presents as … Read more
– Indications: – long acting thiazide like diuretic used in hypertension; – edema associated w/ CHF, cirrhosis, steroid and estrogen therapy; – Adult: 50-100mg POqd; – Contraindications: allergy to sulfa drugs; – Caution with patients w/ impaired hepatic or renal function or SLE; – Peds: 2mg/kg/dose PO 3 times a week
– for insomnia, used as a sedatvie especially in children; also use as preoperative sedative; sedative hypnotic, non barbiturate; – Adult: 500mg-1gm PO or PR qhs prn (max 2gm/day); – Causes gastric and mucosal irritation; – Contraindicated with marked hepatic or renal impairment, or with severe cardiac disease; – Use with caution w/concomitant oral anticoagulant use … Read more
– See: Skin Prep – Discussion: (chloroprep) – kills cells by disrupting their cell membranes and precipitating cell contents; – it has extremely low toxicity even when used on the intact skin of new borns; – in comparison to alcohols, antibacterial activity of chlorohexidine gluconate is not as rapid, but the drug remains … Read more