Nitroprusside: Toxicity
– Discussion: – therapy for > 24 hrs, excessive dosage, or RF may cause acculuation of thiocyanate, the metabolite, is excreted by kidney; – thiocyanatetoxicity occurs at plasma levels of 5-10mg/dl; – look for metabolic acidosis (early sign) blurred vision, tinnitus, or delirium, hepatic dysF(x), dyspnea, V, dizziness, ataxia, and syncope; – metabolic acidosis is … Read more
