Ortho Oracle - orthopaedic operative atlas

Thromboxane

– Discussion:  – principal metabolite of arachidonic acid in platelets;  – stimulates platelet activation, and assists in intravascular aggregation of platelets;  – ASA irreversibly inhibits cyclooxygenase by acetylation of serine residue at its active site;     – cyclooxygenase must be continuously produced in endothelial cells, since they recover their ability to synthesize Prostacyclin within a           few hours; … Read more

Throwing Injuries

– See:       – Throwing Elbow:                – MCL of elbow:               – Diff Dx Pediatric Throwing Elbow       – Throwing Shoulder: Throwing Guidelines:     – 8-10 year olds: 37 to 67 pitches in approximately 1.5 to 2.5 games per week.     – 11-12 year olds: 50 to 86 pitches in approximately 1.5 to 2.5 games … Read more

DVT Treatment – Thrombolytics

Tenecteplase (TNKase) modified version of alteplase with longer half-life, so it can be given as a single bolus over 5-second infusion availability – 10 mL syringe indication (non-comprehensive) reduce mortality associated with acute myocardial infarction Urokinase (Abbokinase) used clinically as a thrombolytic agent, often referred to as a “blood clot buster” drug availability – in … Read more

Thrombolytic Therapy

– See:       – Coag Path       – Deep Venous Thrombosis       – Endothelium       – PT/PTT       – Pharmocological Agents in Vascular Surgery       – Pulmonary Embolism       – Vascular Problems of the Wrist and Hand Acute lower limb ischemia: failure of … Read more

Thrombocytosis

Platelets: 150,000-450,000 uL;  – Increased:        – Sudden Exercise, after Trauma        – Bone Fr(x), after Asphyxia        – Post Surgery (esp Splenectomy)        – Acute Hemorrhage        – Polycythmia vera        – Primary Thrombocythemia        – Leukemias        – Post Partum        – Carcinoma   Digital Ischemia Due to Essential Thrombocythemia: A Case Report

Thrombocytopenia/Platlet Dysfunction

– See: – Bld Prod Menu / – Platlet Transfusion – Discussion:   – manifestations: – vessel or platlet abnormalities: – these present with petechiae, purpura, or easy bruising; – bleeding characteristically occurs superficially (bleeding from mucus membranes or from IV sites); – bleeding from scury shows perifolicular hemorrhages, gingival bleeding, and intramuscular hematomas;     … Read more

Three Part Proximal Humerus Fractures

– See: Three Part Fracture Dislocation and Four Part Fracture – Discussion: – tuberosity frag + displaced surgical neck fragment; – unstable shafts may be driven into mass of deltoid muscle & may be anterior to the proximal fragment; – poor bone contact will lead to delayed or nonunion in most cases; – subtypes: – greater … Read more