Data Trace Editor Foot Ankle Int. 2008 Feb;29(2):256-264 Guyer AJ, Richardson G ABSTRACT Many orthopaedic surgeons had abandoned the use of first and second generation total ankle arthroplasties due to unacceptably high complication and failure rates as compared to arthrodesis. Recently, there has been renewed interest in ankle joint replacement as longer term outcome studies have become … Read more
B. Define and demonstrate debridement I. Introduction A. Debridement derived from French verb “débrider” B. Initially used to denote action of “cutting certain parts which—like a bridle—constrict or strangulate the organs which they cover”2,3 C. Goal of surgical debridement 1. save lives 2. preserve function 3. remove contaminants … Read more
– Discussion: – third generation cephalosporin; – adult: 1-2gm IV q12-24hr; t1/2=7.5hr; w/ long half life, allows once a day dosing, and home treatment; – peds: 100 mg/kg/day q12 or q24hr; – no need to change w/ renal failure; – broad spectrum Gm neg and … Read more
– Discussion: – second generation ceph – cefuroxime is effective in therapy of cases of community-acquired pneumonia in which ampicillin-resistant H. influenzae is a possible etiologic agent cefoxitin; – adult dose: – 0.75-1.5gm q6-8hr IV or 3gm q8hr IV w/ meningitis; … Read more
– Dicussion: – anitdepression aget; – starting dose begins with 20 mg PO qd
– Third Generation Cephalosporin – Do Not use alone with Pseudomonas; – Adult: 100-150mg/kg/24hr q8-12hr IV; t1/2 = 2.5hr; – Hepatic and renal excretion allows normal dosing in Renal failure; – Disulfiram reaction and hypothrombinemia; – Good diffusion from blood into CSF only with inflammation; – Dosing Regimens for Patients with Renal Insufficiency: (Dose for … Read more
– Third Generation Cephalosporin – 100-200mg/kg/24hr; 1-2gm IV q4-6hr; – good Gm Neg coverage; Broad spectrum Gm Neg and Pos; – Treatment of gonorrhea: 1gm IV single dose; – Uncomplicated infections: 1gm IV/IM q12hr; – Moderate to severe infections:1-2gm IV/IM q8hr; – Septicemia and life threatening infections: 2gm IV q4hr; – Prevention of postoperative infections: … Read more
– Gram Pos (Not enterococci, MRSA, Listeria) – Gram Neg (h. influenza, E. coli, Proteus, Klebsiella, M.catarhalis, Proteus, N.gonorrhea) (Not Pseudomonas, Enterobacter, Serratia) – Dose: 1 gm q8hr to 2 gm q4 hr (non absorbed) IM or IV – serum binding 65-79% – Check PT time, preexisting coagulopathy is a relative contraindication
– Second Generation Ceph – Adult: 1-2gm q4-8hr IM/IV;t1/2=.5 hr; – or try:1-2gm q6-8hr IV to max dose 12gm/day (2gm q4hr); – for surgical prophylaxis:2gm IV/IM 30min prior to surgery then 2gm q6hr for 24hr( 72hr for prosthetic arthroplasty); – Res to B. Lactamase; good for: B.fragilis, aerobic and anaerobic; N.gonorrhea, and surgery; – … Read more
– See: Third Generation Cephalosporin – Adults: 25 to 150 mg/kg/day IV; – Peds: 100-150 mg/kg/day q8hr; – good for Pseudomonas, Gm Neg Eneteric, NonEnterococci Strep; moderate to poor activity against strep; mod to good (85%) against Staph; – No activity against B.fragilis or enterococci; – Uncomplicated UTI: 250mg IV/IM q12hr; – Complicated UTI: 500mg-1gm IV/IM … Read more