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Wheeless' Textbook of Orthopaedics
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Work Up of the Painful Total Knee Arthroplasty


- See: TKR Menu

- Natural History of Painful TKR:
    - references:
              - Pain and Depression Influence Outcome 5 Years after Knee Replacement Surgery.
              - Impact of Psychological Distress on Pain and Function Following Knee Arthroplasty


- Potential Causes of TKR failure:

    - early failures:
          - references:
                - Early failures in total knee arthroplasty.
                - Early failures among 7,174 primary total knee replacements: a follow-up study from the Norwegian Arthroplasty Register 1994-2000.  
    - infected TKR
          - bone scans:
                - may indicate loosening after 6-12 months, but can not distinguish between septic and aseptic loosening; 
          - aspiration: for gm stain & culture:
                - most accurate method of dx, and is required prior to all revisions;
                - remember that knee aspiration can yield false positives up to 25% of the time; 
          - sed rate and CRP
                - Use of Erythrocyte Sedimentation Rate and C-Reactive Protein Level to Diagnose Infection Before Revision Total Knee Arthroplasty

    - component misplacement:
          - rotation of the femoral component:
          - rotation of tibial component:
          - references:
                - Rotational malalignment of the femoral component in total knee arthroplasty.
                - Rotational malalignment of the components may cause chronic pain or early failure in total knee arthroplasty.
    - mis-sizing of components
          - tibial overhang;
          - over-sizing the femoral component;
    - knee arthroplasty instability:
    - patellar problems:
          - patellar frx
          - patellar clunk syndrome
          - patellar subluxation
          - eccentric patellar button placement (causing patellar tilt and contact between the lateral patellar facet and the lateral femoral condyle);
          - asymmetric patellar resurfacing:
                - tendency to underresface the medial patellar facet;
    - component failure:
          - fibrous ingrowth:
                - pain resulting from fibrous ingrowth should always be considered in a patient with a press fit femoral or tibial component;
          - polyethylene failure:
                - look for asymmetrical polyethylene thickness;
                - polyethylene may wear out, especially postero-medially;
                - may be associated w/ osteolysis;
                - polyethylene wear may yield green fluid aspirate;
          - tibial component frx:
          - patellar frx:



- Radiographs:
    - comparing sunrise views and lateral films to the native knee (or ipsilateral pre-op films) can help clarify patellofemoral problems
          (tracking, "stuffed" patellofemoral joint, lateral facet contact due to an undersized component, etc.)
    - component loosening:
           - loosening w/ knee replacements is most often due to subsidence, in which component actually sinks into bone;
                    - malalignment, esp. varus alignment, usually has a causal relationship to this failure mode;
           - when its unclear whether loosening or slight subsidence is present, consider obtaining radiographs under flouroscopic control;
                    - also consider need for subtraction arthrogram inorder to emphasize the space between bone
                             and cement or between cement and prosthesis;
                    - also indicated for sublte femoral component loosening, which is difficult to diagnose on plain radiographs;
                    - in study by Vyskocil et al, JBJS 1999, authors found that flourscopically assisted xrays identified significantly more radioluncent lines in femoral
                             components than were found by conventional xrays;
                             - authors note that deviation of x-ray beam of only 2.3 deg to component interface could obscure a radiolucent line of 2 mm, but despite this,
                                      authors were unable to demonstrate a significant advantage to flouroscopically assisted radiographs to detect tibial loosening;
      - references:
             - Radioluncent lines and component stability in knee arthroplasty.  Standard versus flouroscopically assisted radiographs.
                         P. Vyskocil et al.  JBJS. Vol 81-B. No 1. Jan 1999. p 24.
             - Fluoroscopic evaluation of the painful total knee arthroplasty.
             - Radionuclide imaging of asymptomatic versus symptomatic total knee arthroplasties.



- Treatment Options:
 - Role of Arthroscopy following TKR:
 - Revision TKR
 - Physical Therapy following TKR






Mechanisms of failure of the femoral and tibial components in total knee arthroplasty.

Understanding pain in osteoarthritis



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Original Text by Clifford R. Wheeless, III, MD.

Last updated by Clifford R. Wheeless, III, MD on Monday, March 10, 2008 5:30 pm