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Sucralfate/Carafate


 - Discussion: 
- for short term treatment of duodenal ulcers, gastric ulcers, 
- provides local acid resistant barrier, inhibits pepsin; 
- constipation may be a frequent side effect; 
- may be of benefit in intubated patients 
- does not increase gastric pH 
- because of risk of aluminum toxicity, (released when compound ionizes), sucralfate is not used in renal failure
- do not use w/ gastric stasis (may give rise to benzoars); 
- Adult Dosing: 
- 1gm PO qid, 1 hr AC and HS; 
- should be taken on an empty stomach; 
- antacid may also be used if taken 1/2 hr prior to or after sucralfate; 
- treatment should be continued for 4-8 weeks; 
Carafate: Drug Interactions and Toxicities: 
- Absorption & Bioavailability of following are Reduced: 
- Ciprofloxacin and Norfloxacin 
- theophylline and Aminophylline 
- Tetracycline 
- Phenytoin 
- Digoxin 
- Amitriptyline
- (the bioavailability of Digoxin, tetracycline, and phenytoin was not reduced when they were given two hours before sucralfate) 


Sucralfate does not reduce the risk of acid aspiration pneumonitis.