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Home » Ortho Related » Medications » Sulindac/Clinoril


- for rheumatoid and osteoarthritis, and anlkylosing spondylitis;
- Acute gouty arthritis;
- Acute bursitis/subacromial buritis or tendinitis/supraspinatus tendinitis;
- NSAIA; Dose:150-200mg PO bid with food;
- increase as needed to maximum 400mg/day;
- Should be administered with food;
- Contraindicated with: patients w/ h/o asthma, urticaria, or rhinitis precipitated by ASA or NSAIA;
- Contra w/ PUD, and GI bleeding (can occur w/ Sulindac), hemhorrhagic disorders, elderly;
- Closely monitor patients w/ HTN, impaired renal F(x), hepatic F(x), cardiac F(x) or in any condition predisposing to fluid retention;
- Interacts w/ oral anticoagulants to increase PT, reduce dose w/ renal impairment;
- Supplied: 150, 200 mg;
- is a pro-drugs, with the active drug being produced in vivo;
-  becuase sulindac does not seem to affect renal synthesis of prostaglandins as much as other NSAIDs, it should be preferred in patients with renal disease or threatened renal perfusion, such as those who are hypovolemic

Effects of sulindac and ibuprofen in patients with chronic glomerular disease. Evidence for the dependence of renal function on prostacyclin.