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Biochemistry of Skeletal Muscle Contraction

• Muscle Contraction
• Depolarization
• Metabolic Sequence
• Calcium Regulation of Muscle Contraction
• Histology of Skeletal Muscle
• Chemistry of Skeletal Muscle

Muscle Cramps »

Extra cellular Matrix

• composed of many different molecular components, consisting mostly of collagens, proteoglycans, and glycosaminoglycans

Matrix metalloproteinases

• enzymes that digest collagen which are synthesized and excreted by fibroblasts
• required for homeostasis
• disruption of MMP regulation due to injury / disease can alter normal ECM architecture and prevent proper force transmission;
• zinc-dependent endopeptidases that digest collagen and other structural molecules
• 4 types:
  • collagenases, gelatinases, membrane-bound MMPs, and stromelysins

DHEA effect on muscle:

• DHEA Alleviates Oxidative Stress of Muscle Cells via Activation of Nrf2 Pathway.
• Effect of dehydroepiandrosterone administration on recovery from mix-type exercise training-induced muscle damage.
• Specific binding and effects of DHEA-S on skeletal muscle cells: implication for DHEA-S replacement therapy in myotonic dystrophy.

Additional Information

• Phys Ed: Does Stretching Before Running Prevent Injuries?
• Phys Ed: The Workout Enigma
• Fighting the Muscle Loss That Comes With Age
• More Than an Exercise in Vanity
• Suturing of lacerations of skeletal muscle
• A Muscular Twist on the Fate of Fat