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- Discussion:
    - is bactericidal antibiotic active only against Gm Pos organisms and a few gm neg organisms such as GC and Meningococci;
    - commonly used topically and is effective PO in Rx of C.difficile colitis;
    - apply ointment to area one or more times daily;
    - bacitracin in concentrations as low as 50,000 units/L and polymyxin in concentrations as low as 50 mg/liter sterilized all cultures but S. epidermidis and Proteus species;
           - use 50 units per ml for irrigation;

- Cautions:
    - is nephrotoxic and should not be used parentally;
    - will interact with Neuromuscular blocking agents

The use of bacitracin irrigation to prevent infection in postoperative skeletal wounds. An experimental study.

Acute renal failure after total hip replacement.

A Randomized Prospective Study of Topical Antimicrobial Agents on Skin Grafts After Thermal Injury.

Intraoperative anaphylactic shock associated with bacitracin irrigation during revision total knee arthroplasty. A case report.