- prevents conversion of purine bases by suppressing synthesis of guanine and adenosine;
- RA Doses: 1-2.5 mg/kg/day;
- onset of action is usually 12 to 24 weeks;
- discontinuation of the drug is marked by a return in disease activity;
- most common toxicity is gastrointestinal including nausea, anorexia, and, rarely, vomiting and pancreatitis;
- hematologic toxicity including leukopenia, thrombocytopenia, and anemia, may occur and is generally dose dependent.
Influence of methotrexate and azathioprine on radiologic progression in rheumatoid arthritis. A randomized, double-blind study [see comments.]