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Glycosaminoglycans

Discussion

  • glycosaminoglycans are linear polysaccharides composed of repeating disaccharides units, usually more than 20 per chain;
    • glycosaminoglycans attach to a protein core forming a proteoglycan;
  • two major glycosaminoglycans w/ in cartilage ground substance consist of chondroitin sulfate and keratan sulfate;
  • shared characteristics include:
    • straight chains with no branching;
    • disaccharide repeating units of glycosamino-glycans are composed of two monosaccharide units;
    • one unit is always an hexosamine; (amino group of the hexosamine is N-acetylated);
    • second monosaccharide unit consists of the repeating disaccharide is of either hexuronate or galactose;
  • misc: mucopolysaccharidoses are a group of disorders characterized by inability to degrade glycoaminoglycans

References