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Glycosaminoglycans


- Discussion:
- glycosaminoglycans are linear polysaccharides composed of repeating disaccharides units, usually more than 20 per chain;
- glycosaminoglycans attach to a protein core forming a proteoglycan;
- two major glycosaminoglycans w/ in cartilage ground substance consist of chondroitin sulfate and keratan sulfate;
- shared characteristics include:
- straight chains with no branching;
- disaccharide repeating units of glycosamino-glycans are composed of two monosaccharide units;
- one unit is always an hexosamine; (amino group of the hexosamine is N-acetylated);
- second monosaccharide unit consists of the repeating disaccharide is of either hexuronate or galactose;
- misc: mucopolysaccharidoses are a group of disorders characterized by inability to degrade glycoaminoglycans


Characterization of aggregating proteoglycans from the proliferative, maturing, hypertrophic, and calcifying zones of the cartilaginous physis.

Synthesis of chondrocytic keratan sulphate-containing proteoglycans by human chondrosarcoma cells in long-term cell culture.

Hyalograft C: hyaluronan-based scaffolds in tissue-engineered cartilage.