- Discussion: - nondepolarizing neuromuscular blocking agent similar to pancuronium. - has advantages over other nondepolarizing muscle relaxants by producing less hemodynamic changes, a shorter duration of action; - dose reductions are not required in renal failure, but may be indicated in hepatic disease.
- Dose: - usual intraoperative doses are 0.08 to 0.1 mg/kg IV, followed by maintenance doses of 0.01 to 0.015 mg/kg. - dose: 0.25 mg/kg - half-life is 65 to 80 minutes. - Misc: - prior administration of
succinylcholine may enhance the neuromuscular blocking effect and duration of action of vecuronium and therefore dosage should be reduced;
