- Discussion:
- at 2-4th week of development, sclerotome cells arising from paired somites migrate medially & meet in midline around notochord;
- these sclerotome cells separate the notocord from neural tube dorsally and from gut ventrally;
- paraxial mesoderm becomes segmented into four cranial and eight cervical somites at 2-3 weeks;
- sclerotomes form cell masses which forms a condensed layer of cells near its caudal border w/ less condensed mesenchyme both
cranial and caudal to it;
- somites each differentiate into cranial and caudal halves, which then reunite with the caudal and cranial halves, respectively,
of the adjacent somite, forming each provertebra;
- condensed layer migrates cranially to middle of adjacent myotome & differentiates into the anulus fibrosus of intervertebral discs;
- notochord eventually constitutes the apical and alar ligaments as well as the nucleus pulposus of each intervertebral disc;
- caudal portion of each sclerotome fuses w/ superior portion of adjacent sclerotome which will go on to form primordium of vertebral body;;
- as vertebral body develops, portion of notochord within it becomes thinner and ultimately disappears;
- between vertebral bodies, notochord that persists goes on to form intervertebral discs;
- at birth, vertebra consists of three bones joined by cartilage, & osseous union is achieved over a period of years;
- during 16th year, secondary centers of ossification appear in cartilage that still exists over cranial and caudal
ends of vertebral bodies;
- centers of ossification form disc-like epiphyses that unite with bony bodies by the 25th year;
- Development of the Atlas:
- during formation of atlas, body appears, but it is soon appropriated by axis to form the dens;
- as consequence, atlas is essentially neural arch that is closed ventrally to form a ring