Spondyloarthropathies / Related Chronic Seronegative Arthritides
- conditions include:
- Reiter's Syndrome
- Psoriatic Arthritis
- Inflammatory Bowel Disease
- typically involves the axial skeleton;
- affected areas heal w/ fibroblastic proliferation followed by new bone formation;
- pathogenesis of these disorders is unknown except for Reiter's syndrome, which is generally believed to result from aberrant host response to a pathogenic microorganism;
- RF is negative;
- HLA-B27 phenotype:
- typically possitive in seronegative arthritis;
- typically negative in RA;
- Clinical Manifestations:
- Systemic manifestions:
- low grade fever, malaise, wt loss, aortitis.
- look for AR
- iritis assoc seronegative spondyloarthropathies is acute inflammatory process causing redness, pain, and photophobia. (in contrast to JRA it is self limiting and rarely leads to visual impairment.)
- pain at ligament and tendon insertions;
- seen frequently, may occur before back symptoms.
- occurs in: metatarsal heads, plantar fascia, achilles tendon
- less common: tibial tubercle, patella, greater trochanter, iliac crest, sacroiliac joints, and clavicle.
Alternatives to Total Knee Replacement: Autologous Hamstring Resurfacing Arthroplasty
Original Text by Clifford R. Wheeless, III, MD.
Last updated by Data Trace Staff on Tuesday, August 21, 2012 4:42 pm