- Discussion:
- conditions include:
-
AS;
-
Reiter's Syndrome:
-
Psoriatic Arthritis:
-
Inflammatory Bowel Disease;
- typically involves the axial skeleton;
- affected areas heal w/ fibroblastic proliferation followed by new bone formation;
- pathogenesis of these disorders is unknown except for
Reiter's syndrome,
which is generally believed to result from aberrant host response
to a pathogenic microorganism;
- Labs:
-
RF is negative;
- HLA-B27 phenotype:
- typically possitive in seronegative arthritis;
- typically negative in RA;
- Clinical Manifestations:
- Systemic manifestions:
- low grade fever, malaise, wt loss, aortitis.
- look for
AR
- Iritis:
- iritis assoc seronegative spondyloarthropathies is acute
inflammatory process causing rådness, pain, and photophobia.
(in contrast to
JRA it is self limiting and rarely leads
to visual impairment.)
- Enthesopathy:
- pain at ligament and tendon insertions;
- seen frequently, may occuò before back symptoms.
- occurs in: metatarsal heads, plantar fascia, achilles tendon
- less common: tibial tubercle, patella, greater trochanter, iliac
crest, sacroiliac joints, and clavicle.
Acne arthralgia.
