Baclofen



- Discussion:
    - is the drug of choice for spasticity;
    - it potentiates the inhibitory effect of gamma-aminobutyric acid on reflex arcs;
    - adult dosing:
           - typical regimen begins with a dose of 5 mg given orally twice a day, which is increased to the minimal effective dose;
           - reasonable maximal daily dose in a young person is 200 mg (though this exceeds the maximal dose recommended in the package insert).
    - peds dosing:
           - between ages 2-7 yrs old: give 3-5 mg PO tid;
           - dose can be titrated upward in 5 mg increments, q 3days;
           - maximum dose 40 mg per day in order to obtain the desired effect;
           - children greater than 8 years of age max dose is 60 mg per day;
    - cautions:
           - sedation is a common early side effect that may abate; delirium and seizures are rare;
           - abrupt cessation of baclofen can cause dramatic withdrawal syndrome (or seizures), and patients should be cautioned about this;
           - occasionally, a patient is hospitalized because of an unrelated problem, and the baclofen is discontinued, which precipitates
                   withdrawal symptoms and needless investigation



Intrathecal Baclofen For Severe Spinal Spasticity.



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Thursday, May 24, 2012 10:37 am