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Lupus Anticoagulant

- See: Antiphospholipid Antibodies- Discussion:
- is antibody acting on phospholipid of prothrombin activator complex causing an in vitro anticoagulant effect that paradoxically is associated with thrombosis in vivo;
- patients may demonstrate venous and arterial thrombosis and thrombocytopenia;
- there is no agreement as to which group of tests is more sensitive to measure lupus erythematosus anticoagulant;
- plasma showing abnormal activated partial prothrombin time, a positive screening test for lupus anticoagulant, & no evidence of fibrin-fibrinogen degradation products is considered positive for lupus erythematosus anticoagulant;
- patients with lupus average have frequency of 34% for lupus erythematosus anticoagulant and 44% for anticardiolipin antibodies