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Ofloxacin / Floxin

- Dosing:
    - usual dose is 200 mg to 400 mg q 12 hr;
    - 30-40% of drug will be excreted in to urine;
    - there is some evidence for higher tissue concentrations than seen with other antibiotics, and with a 800 mg dose the tissue concentrations are at least 8 times higher than the MIC;

- Drug Interactions:
    - ofloxacin interferes w/ cytochrome P450 enzymes (as w/ other quinolones);
    - will increase PT times in patients taking coumadin;
    - may affect phenytoin levels

Tissue concentrations after a single dose, orally administered ofloxacin in patients with diabetic foot infections.