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- for hypothyroidism, T3 replacement; 
- Adult: initial dose of 25ug/24hr, then titration q1-2 weeks according to clinical response & thyroid function tests to maintenance of 25-75ug PO qd; 
- 25ug equivalent to 1 grain desiccated thyroid or .10 mg of levothyroxine; 
- Reduce dose in elderly