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Diltiazem/Cardizem

(See also: Class IV Agents)

  • For Angina pectoris, HTN;
  • Adults: 30mg PO qid intially, then 180-360 mg/day in divided doses;
    • SR formulations available: 60, 120, 180 mg PO bid;
    • CD form available as 240 mg;
    • may be used in combo w/ NTG, or Beta blockers
  • Precautions:
    • must observe for Bradycardia or Hypotension;
    • bradycardia, & Prolonation of PR interval (slows AV node)
    • contraindicated w/ Sick Sinus Syndrome, 2-3 deg AV block, and hypotension SBP<90 (same contra as Verapamil);
    • causes slight increase in Digitalis levels