- First Generation Ceph
- 1-2gm q4hr IV or 125mg/kg/4-6hr,t1/2=40min;Inject;
- Decrease dose with renal failure;
- 60-70 % of dose will be excreted in urine (w/ nl R F(x))
- Contra with cephalo allergy, caution with penicillin allergy;
- Good diffusion from blood into CSF only with inflammation;
- Note: Ratio of CSF to BloodLevel (%): Normal Meninges: nil
Inflammed Meninges: 13 (if protein >50mg%)
- w/ osteomyelitis
Dose IV time p admin. Mean Ser conc (ug/ml) Mean Bone conc (ug/gm)
1 gm 60 11.9 3.9
25 mg/kg < 50 52.2 1.9
IM:40 mg/kg w0 89 to 107 1.4
Plasmid-encoded enzyme is TEM-1; SHV-1 is also frequent in Klebsiella pneumoniae, and PSE-1 is the most common variety on plasmids in
P. aeruginosa; These enzymes confer resistance to Ampicillin, carbenicillin, Ticarcillin, cephalothin, and cefamandole but not to broad-spectrum cephalosporins, monobactams (Aztreonam), or cephamycins (cefoxitin)
Cephalothin and cefamandole penetration into bone, synovial fluid, and wound drainage fluid.