- low mol. wt. dextran; - adjunct in peripheral vascular surgery;
- works by expanding plasma volume and decrease blood viscosity;
- prophylaxis of DVT and thromboembolism: 10 ml/kg IV on day of surgery followed by 500 ml IV daily for 2-3 days;
- then 500ml IV every 2-3 days based on patient risk factors for thromboembolism for up to 2 weeks;
- Supplied: 10% dextran 40 in 0.9% NaCl or 5% dextrose
References
- Prevention of venous thrombosis after total knee arthroplasty. Comparison of antithrombin III and low-dose heparin with dextran.
- Prophylaxis of deep-vein thrombosis after total hip replacement. Dextran and external pneumatic compression compared with 1.2 or 0.3 gram of aspirin daily.
- Prevention of thrombosis after hip fracture surgery. Comparison of dextran 70 with and without dihydroergotamine.
- Prevention of fatal pulmonary embolism in patients with fractures of the neck of the femur.
- The effect of dextran on microvascular thrombosis in an experimental rabbit model.