Data Trace Editor for severe systemic fungal infections; dose: 0.25mg/kg IV over 6hrs initially (infusion .1mg/ml); gradually increase dose as tolerated up to 1-1.5mg/kg/24hrIV over 6hr; note hypersensitivity, caution with nephrotoxic/antineoplastic agents; monitor blood, liver, and renal function, discontinue therapy if BUN >40mg/dl, Creatinine >3.0mg/dl, or if liver function test abnormalities are noted; should be delivered via Central … Read more
– See: – aminoglycosides – for short term Rx of serious infections from Gm Neg aerobes and penicillinase producing Staph; – Adult: 15 mg/kg/24hr divided over q8-12 hours; – with clearance < 50 ml/min. give dose over 12-18hr; – w/ clearance < 30 give dose over 24-36 hr; – Peds: … Read more
for HTN possibly indicated in reperusion injury to protect against calcium paradox in crushed skeletal muscles; massive simultaneous volume replacement would be needed to prevent additional depletion of intravascular volume by these agents. K+ sparing diuretic; Adult: 5mg PO qd; increase to 10mg if needed
– amicar may be harmful in disseminated intravascular coagulation, and this disorder should be reasonable r/o out before administration of this agent; – consider 3 – 5 gm IV load and 1 gm IV q1hr times 5 hours
– Specific Agents: – Neomycin – Gentamicin – Tobramycin – Amikacin – Netilmicin – Discussion: – indicated for serious Gm Neg infections caused by suseptable pseudomonas, proteus, e. coli, klebsiella, enterobacter sp., serratia, and gm neg sepsis; – tobramycin is more … Read more
– See addition of antiobiotics to cement discussion – tobramycin: – has rapid elution of antibiotics which diminishes quickly after 2 weeks; – of interest, some bacteria will be able to survive on tobra or vanco beads alone, but generally cannot survive when both antibiotics are added to cement mixture; – the addition of 3.6 … Read more
– for Asthma, bronchospasm; – Adult Loading Dose: 6mg/kg IV over 20 min; – maintenance 0.6 mg/kg/hr IV infusion; w/ CHF, Liver dz, or elderly pts maintenance dose = 0.3 mg/kg/hr IV; – will need to individualize doses; – Acute Asthmatic Attack: Load 6mg/kg IV, then 1 mg/kg/hr IV; – Watch serum values: 10-20ug/ml is … Read more
Discussion for anxiety disorders, benzodiazepine, cross tolerant w/ ETOH; Adult: 0.25-0.5mg PO tid; max dose= 4mg/day; reduce dose in elderly; Peak plasma PO [ in 1-2hr w/ t/2== 6-20 hr
– Discussion: – for hyperacidity in PUD, hiatial hernia, esophagitis, gastritis by neutralizing gastric acid; and hyperphosphatemia; acts as Antacid; – Adult: 10-30ml or 1-2 tab (.6gm) PO 4-6x qd; – Side Effects: – Poor Choice with Renal Insufficiency (Aluminum toxicity) – Do not use with patients taking tetracycline; – may cause hypokalemia; – Peds: … Read more
– provides an assessment of alveolar-capillary gas exchange. – normal gradient is 20 – 65; Gradients > than 400 = severe Resp distress; – calculation requires: paO2 & PAO2; – place on 100% O2 for 20 min; PAO2 then = 673 (pCO2 = 47) – then get @O3.HLX^LABABG[ABG and calc difference; 673 – pO2. – … Read more