Ortho-Preferred

Verapamil/Calan


- See: 
- Class IV Agents 
- Discussion: 
- Ca channel blocker, prolongs AV conduction, slows sinus rate, & exerts Negative Inotropic effect; 
- Useful for converting narrow complex SVT to sinus rhythm in stable patients if carotid sinus massage unsuccesful; 
- Useful for Unstable Angina, HTN, A.fib & A. Flutter (except when A.fib/flutter is associatted with bypass tracts 
- see WPW 
- Will Not convert A.fib to normal sinus rhythym; 
- Not used for Ventricular arrhytmia; 
- Interactions: 
- may increase Digoxin levels by 50-75%;
- Cimetidine will reduce clearance (incr blood concentration) 
- contraindicated w/ use of Beta blockers, 2nd or 3rd AV block; 
- Acute Arrhythmia: 
- 5-10mg IV bolus (.075-.15mg/kg) over 2-3 min, w/ dose repeated q15-30 min as needed and tolerated; 
- Dosing for Adults
- 80 mg PO tid/qid initially; 
- Angina: 120-480mg/24hr in 3-4 divided doses; 
- Max dose: 480mg/day in patients with Angina
- HTN: 80mg PO tid or SR tab: 240 mg PO qd 


 
Verapamil enhances the survival of primary ischemic venous obstructed rodent skin flaps

Efficacy of verapamil in the salvage of failing random skin flaps.

 




Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Monday, December 19, 2011 1:17 pm