- See: -
Class IV Agents
- Discussion: - Ca channel blocker, prolongs AV conduction, slows sinus rate, & exerts Negative Inotropic effect; - Useful for converting narrow complex
SVT to sinus rhythm in stable patients if carotid sinus massage unsuccesful; - Useful for Unstable
Angina,
HTN,
A.fib &
A. Flutter (except when
A.fib/
flutter is associatted with bypass tracts - see
WPW -
Will Not convert A.fib to normal sinus rhythym; - Not used for Ventricular arrhytmia;
- Interactions: - may increase
Digoxin levels by 50-75%; -
Cimetidine will reduce clearance (incr blood concentration) - contraindicated w/ use of
Beta blockers, 2nd or 3rd AV block;
- Acute Arrhythmia: - 5-10mg IV bolus (.075-.15mg/kg) over 2-3 min, w/ dose repeated q15-30 min as needed and tolerated; -
Dosing for Adults: - 80 mg PO tid/qid initially; -
Angina: 120-480mg/24hr in 3-4 divided doses; - Max dose: 480mg/day in patients with
Angina; -
HTN: 80mg PO tid or SR tab: 240 mg PO qd; ---------------------------------
Verapamil enhances the survival of primary ischemic venous obstructed rodent skin flaps.
Efficacy of verapamil in the salvage of failing random skin flaps. 
