Type II Collagen


- See: collagen

- Discussion:
    - accounts for over 50 percent of the dry wt of cartilage;
    - type II collagen is also found in small amounts in vitreous gel and in a number of other tissues during early development;
    - type II collagen mutations:
           - mutations in type II collagen as a cause of chondrodysplasias:
           - chondrodysplasias are highly heterogeneous group of heritable dzes of cartilage characterized by dwarfism, joint
                   deformities, and other skeletal anomalies;
           - since the strength of cartilage depends largely on presence of fibrils of type II collagen, it is possible that some
                   chondro-dysplasias are caused by
                   mutations in type II procollagen that are similar to mutations in type I procollagen that cause osteogenesis imperfecta;
           - specific disorders that may be caused by type II collagen mutations:
                   - spondyloepiphyseal dysplasia, Kniest dysplasia, and Stickler syndrome




Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Tuesday, July 5, 2016 5:25 am