- Discussion:
- for primary
TB, treatment of assymptomatic carriers of N. meningitidis to eliminate meningococci from the nasopharynx;
- it inhibits bacterial DNA dependent RNA polymerase activity;
- note that rifampin should be administered 1hr before, or 2hr after a meal;
- contraindicated with a h/o of hypersensitivity to rifampin;
- use with caution in patients taking
coumadin (incr requirments), liver dz,
- use w/ caution with isoniazid (increased hepatotoxicty);
- note: diffusion from blood into CSF adequate w/ or w/o Inflammation;
- dosing regimens for patients with renal insufficiency: (for 70 kg Adult)
- gm/dosing interval in hours: CrCl: >80:0.3-0.6/24;
50-79:0.3-0.6/24; 30-49: 0.3-0.6/24;
10-29: 0.3-0.6/24;
- 6-30% of drug will be excreted in to urine (w/ nl RF(x))
-
adult dosing:
- pulmonary TB: 600mg PO qd;
- for meningococcal carriers: 600mg PO qd;
-
peds: meningococcus prophylaxis: 10 mg/kg/day qd x 3 days;
-
supplied: tab 300 mg;
Staphylococcus aureus nasal carriage and infection in patients on hemodialysis. Efficacy of antibiotic prophylaxis.
Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group.
