- RA may cause symptoms because of pressure and location;
- nodules may be cosmetically unacceptable;
- nodulosis occurs in 20-25% of patients with RA
- associated with strong seropositivity;
- implies aggressive disease with poor prognosis;
- may occur in benign form of RA manifested by nodulosis & mild polyarthralgias;
- contain central area of necrotic fibrous & palisades of epithelioid cells inside of an outer zone of chronic inflammatory cells;
- not a priority unless erosion, pain, or infection present;
- cosmesis is factor if disfigurment of hand and forearms is major concern to patient;
- nodules may recurr after resection;
- steroid injection can cause to regress, may cause ulceration of nodule
- careful dissection of nodule from skin meticulous hemostasis necessary
- protect nerves when applicable
The subcutaneous rheumatoid nodule.
Original Text by Clifford R. Wheeless, III, MD.
Last updated by Data Trace Staff on Tuesday, August 21, 2012 1:44 pm