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Osteomalacia - Rickets: Gastrointestinal and Bilary Causes



- See: Vitamin D Defiency Rickets;

- Discussion:
    - following a Polya or Billroth II gastrectomy, osteomalacia develops that was quite subtle and
            only revealed itself by increasing muscle weakness or a pathological fracture;
    - abnormal fat metabolism, usually associated w/ failure of emulsifying action of bile salts or
            presence of free fat in intestinal tract;
    - diffuse injury to the wall of small bowel, as occurs with inflammatory processes such as celiac
            disease, Crohn disease, or disorders associated with a short loop (shunts or fistulae) or rapid
            transit (gluten-sensitive enteropathy and other sprue-like syndromes);
    - absorption characteristics:
          - approximately 20% of oral calcium is absorbed by the gut under normal conditions;
          - requires physiologic gastric acidity and normal bowel and pancreatic funciton;
    - substances that interfere w/ calcium absorption:
            - excessive fatty acids bind calcium and prevent absorption;
            - phytic acids (found in wheat and tea);
            - excessive phosphorous (as in soft drinks) binds Ca and prevents absorption;
            - oxylates (found in spinach);
            - excessive phosphorous (as in soft drinks) binds Ca and prevents absorption;
                  - excessive fatty acids bind calcium and prevent absorption;
                  - phytic acids (found in wheat and tea);







Original Text by Clifford R. Wheeless, III, MD.