- See:
-
Penicillin Family
-
AntiPseudo
- Adult: 2-4gm q4-6hr Injection; or 200-300 mg/kg/24hr; 1.85mEq Na/gm;
- More active than
Ticarcillin against Enterobacteriacae,
same activity against
P.aeruginosa;
good activity against B.fragilis;
- Diffusion from blood into CSF adequate w/ or w/o Inflammation; Ratio of
CSF to Blood Level (%): Normal Meninges: ; Inflammed Meninges: 20;
Dosing Regimens for Patients with Renal Insufficiency: (Dose for 70 kg
Adult {gm/dosing interval in hours}):CrCl:>80:3/4-6; CrCl:50-79:3/4-6;
CrCl:30-49:3/6; CrCl:10-29:3/6-8;
- 60% of drug will be excreted in to urine (w/ nl RF(x))
- Will interact with
aminoglycosides, Oral Anticoagulants, Oral contra;
