Hyaluronic acid

- See:  osteoarthritis of the knee

- Discussion:
    - hyaluronic acid is a glycosaminoglycan found in synovial fluid & cartilage
    - complex sugar (not a protein)
    - ancient molecule, highly conserved- identical
    - function:
          - acts as lubricant and shock absorber;
          - acts as barrier permitting metabolites to pass thru it by diffusion but resists penetration by bacteria and other infectious agents; 
          - most hygroscopic molecule in the human body
    - presence in cartilage:
          - amount in cartilage is variable but usually represents less than 1% of total glycosaminoglycans;
          - can be present in a free state, but it is usually found as a part of proteoglycan aggregates in cartilage; 
          - maintenance of physico-chemical characteristics of cartilage extracellular matrix
    - presence in synovial fluid
          - in joint fluid, hyaluronic acid is synthesized in synovial membrane;
          - hyaluronate in synovial fluid is an extended glycosaminoglycan and a lubricating glycoprotein;
          - sheer stiffness (determines elastic behavior) of synovial fluid is derived from the entanglement of these long-chain molecules
                   and remains constant;
          - may have an antiinflammatory effect and an antioxidative effect

Effect of hyaluronic acid/chondroitin sulfate on healing of full-thickness tendon lacerations in rabbits.

Hyaluronans: is clinical effectiveness dependent on molecular weight?

Granulomatous inflammation after Hylan G-F 20 viscosupplementation of the knee : a report of six cases.

Increased Frequency of Acute Local Reaction to Intra-Articular Hylan GF-20 (Synvisc) in Patients Receiving More Than One Course of Treatment 

Hyaluronan Suppresses IL-1[beta]-induced Metalloproteinase Activity from Synovial Tissue

Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Wednesday, July 6, 2016 3:45 am