Glycosaminoglycans



- Discussion:
    - glycosaminoglycans are linear polysaccharides composed of repeating disaccharides units, usually more than 20 per chain;
          - glycosaminoglycans attach to a protein core forming a proteoglycan;
    - two major glycosaminoglycans w/ in cartilage ground substance consist of chondroitin sulfate and keratan sulfate;
    - shared characteristics include:
          - straight chains with no branching;
          - disaccharide repeating units of glycosamino-glycans are composed of two monosaccharide units;
          - one unit is always an hexosamine; (amino group of the hexosamine is N-acetylated);
          - second monosaccharide unit consists of the repeating disaccharide is of either hexuronate or galactose;
    - misc: mucopolysaccharidoses are a group of disorders characterized by inability to degrade glycoaminoglycans



Characterization of aggregating proteoglycans from the proliferative, maturing, hypertrophic, and calcifying zones of the cartilaginous physis.

Synthesis of chondrocytic keratan sulphate-containing proteoglycans by human chondrosarcoma cells in long-term cell culture.

Hyalograft C: hyaluronan-based scaffolds in tissue-engineered cartilage.



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Friday, June 1, 2012 11:08 am