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Wheeless' Textbook of Orthopaedics
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Fluid Management in the Trauma Patient



- See:
      - Transfusion Menu / Blood Product Menu:
      - Subclavian Vein Catheterization and Internal Jugular Approach

- Adult Trauma Patient:
    - initially the adult trauma pt should rapidly be given 2 liters of a balanced salt solution w/ observation of response;                  
    - if there is no improvement in vital functions, than an additional fluid load should be instituted with the addition of pRBC;                
    - the use of naloxonne, vasopressors, diuretics, and bicarbonate is rarely indicated in the initial resuscitation of the trauma patient;        
    - in early shock, tachnypnea leads to respiratory alkalosis followed by metabolic acidosis due to poor tissue perfusion and will reverse w/ adequate
           volume has been restored;                                  
    - as long as the pt is in the supine position, as much as 1000 ml of blood may be maintained w/o causing a significant increase in peripheral pulse;
    - many trauma pts will have elevated levels of antidiuretic hormone from trauma, whether or not shock has occurred;                              
    - caution must be observed in allowing water intake, as dangerous water intoxication may occur with the intense thirst stimulus;            
    - serial hematocrit:
    - classification of hemorrhage:
           - 70 kg male holds approximately 5 liters of blood or equivalent of 25 units pRBC;
           - class I:
                   - loss of upto 15% of the blood volume or 4 units pRBC loss;
                   - normally does not cause a change in blood volume or pressure;
           - class II:
                   - loss of 15% to 30% of blood volume or 4-8 pRBC loss;
                   - normally results in increased pulse but no change in blood pressure;
           - class III:
                   - loss of 30% to 40% of circulating blood volume which is about 2 liters;
                   - this results in tachycardia and loss of blood pressure;
           - class IV:
                   - loss of more than 40% of blood volume;


- Resusitation for Infants and Children:
    - LR bolus 20 ml/kg x 2-3 as required                                    
    - then pRBC 10 ml/kg x 1                                                  
    - continue fluid administration until CVP > 5 mm Hg;                      



- Daily Fluid Requirements:
    - minimum requirements for fluid balance can be estimated from the sum of the urine output necessary to excrete the daily
           solute load (500 ml/ day) plus insensible (evaporative) water losses from the skin and resp  
           tract (500-1000 ml/day) minus the amount of water produced from endo-genous metabolism (300 ml/day);                                          
    - the kidney must excrete about 600 mOsm of solute/day (primarily Na, K, and urea) in the normal adult;                                      
    - since the maximum urinary concentrating ability is 1200 mOsm/kg, the minimum urine output required to excrete the osmotic load is 500 ml/day;                                                        
    - it is customary to administer 2000-3000 ml of water daily to      
             produce about 1000-1500 ml/day urine output, since there is no
             advantage gained by minimizing urine output;                  



- Types of Fluids:
    - crystalloid:
           - the major disadvantage of isotonic crystalloids is their limited ability to remain within the intravascular space;
           - LR by the end of a 1 liter infusion expands the intravascular compartment by only 194 ml;                                                      
           - the remaining 80% of fluid is lost to the intersitial space;        
           - generally, two to four times as much crystalloid as 5% albumin or 6% hetastarch is required to achieve
                   the same physiologic endpoints;    
    - colloids:
           - greater ability to than crystalloids to remain within the intravascular   space and therefore more efficient volume expanders;                  
           - approximately 90% of exogenous albumin can be found in the IV space 2 hrs after administered;                                              
           - the serum half life of albumin is about 18 hrs;                          
           - synthetic colloids such as (hetastarch, hespan) have similar volume expanding abilities;                                              
    - plasmanate (plasma protein fraction)
           - is a 5% protein solution containing both albumin and alpha and beta globulins;                              
           - paradoxical hypotension has been noted during the infusion of plasma protein fraction and has been attributed
                  to acetate, present as a buffer, or the presence of Hageman factor fragments;                






Hemoglobin drops within minutes of injuries and predicts need for an intervention to stop hemorrhage.










Original Text by Clifford R. Wheeless, III, MD.