Fresh Frozen Plasma
- transfusion therapy
- Volume: Approximately 200mL;
- Dose: 2 units FFP
- Maximum admistration time: 4 hrs;
- Rate of infusion: depends on patient's clinical condition;
- Indications: Bleeding w/ labile Coagulation factor deficiencies; (Factor V or VIII)
- Note: Must allow 20-30min to thaw;
- FFP contains all clotting factors including the labile factors V and VIII as well as 250 to 400 mg of Fibrinogen;
- FFP contains anti-erythrocyte antibodies, & is given type specific product;
- after every 6 units of blood is given, two units of FFP is given, and after every ten units of blood, six units of platelets should be infused;
- effectiveness of FFP will lapse within hours, requiring administration;
- FFP has been associatted with non cardiac pulmonary edema;
- one should not administer FFP to correct clotting studies unless the patient shows excess bleeding
- Effect of fresh-frozen plasma resuscitation on cardiopulmonary function and serum protein flux.
- Fresh frozen plasma supplement to massive red blood cell transfusion.
- Evolution of a multidisciplinary clinical pathway for the management of unstable patients with pelvic fractures.
- Fresh frozen plasma should be given earlier to patients requiring massive transfusion.
Original Text by Clifford R. Wheeless, III, MD.
Last updated by Data Trace Staff on Wednesday, April 11, 2012 3:03 pm