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Wheeless' Textbook of Orthopaedics

Cardiac Enzymes



- See: Laboratory Menu:

- CPK:
    - normal values:
            - men: less than 174 Units/liter
            - women: less than 140 Units/liter
            - isoenzymes: MM 100%, MB (cardiac) and BB (brain) normally comprise 0%;
    - abnormal values:
            - myocardial infarct
                   - CPK levels begin to rise 4-6 hours after MI has started and reaches its peack values within 30 hrs;
                   - look for an elevation of the CPK MB isoenzymes at 4-6 hours (in MI the CPK MB is more than 5% of total CPK);
            - post surgical elevation: there will be an elevation of the CPK level, but the CPK MB percentage should be close to 0;
            - polymyositis

- Troponin I and T:
    - these are cardiac specific muscle proteins which are elevated with cardiac muscle damage;
    - references:
            - Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin T or I.
                    CW Hamm MD et al.  New England Journal of Medicine. Dec 4. 1997 p 1648.
            - A proposed strategy for utilization of creatinine kinase MB and Troponin I in the evaluation of acute chest pain.
                    CA Polanczyk MD et al.  Am. J. Cardiology Vol 83. 1999. p 1175-1179.














Serum CPK and LDH after anterior approaches to the thoracic and lumbar spine.

Serum CK-MB is useful in diagnosis of acute myocardial infarction after total hip arthroplasty.

Cardiac isoenzyme values after total joint arthroplasty.

Creatine kinase MB in skeletal muscle and serum of spine-fusion patients.

Perioperative creatine phosphokinase (CPK) and troponin I trends after elective hip surgery.











Original Text by Clifford R. Wheeless, III, MD.