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Duke Orthopaedics
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Wheeless' Textbook of Orthopaedics

Bone Remodeling


- See: Essentials in Osteodynamics"

- Discussion:
    - bone remodeling functions reshaping or replacement of of bone during growth and following injury;
           - in the first year of life, almost 100% of the skeleton is replaced;
           - in adults, remodeling procedes at about 10% per year;
    - bone responds to functional demands and muscle attachments;
    - w/ remodeling, bone will be added where needed and removed where it is not required;
    - bone remodeling begins w/ bone resorption, followed by subsequent by bone formation;
           - remodeling process occurs w/ a specific sequence of events termed the Bone multicellular unit (BMU);
    - sequence of events;
           - remodeling may begin w/ parathyroid hormone induced resorption;
           - osteoclastics resorb bone removing both organic and inorganic components are removed;
           - subsequently, new bone by osteoblasts, replacing bone that was resorbed;

- Wolfe's Law:              
    - described by Julius Wolff in 1868.
    - law holds that every change in the form or function of a bone is followed by adaptive changes in its internal architecture and its external shape





Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Tuesday, September 13, 2011 1:32 pm