- Discussion:
     - two-stage technique: first, debridement and filling of bone loss with an acrylic spacer
               - original technique used external fixator, but new techniques use IM nail;
     - second, bone reconstruction by filling with cancellous bone in the space left free (following cement removal) inside the so-called self-induced periosteal membrane

     - references:
              - Staged Bone Grafting Following Placement of an Antibiotic Spacer Block for the Management of Segmental Long Bone Defects
              - Masquelet technique for reconstruction of osseous defects in a gunshot fracture of the proximal thigh--a case study.
              - The concept of induced membrane for reconstruction of long bone defects.
              - Induced membranes secrete growth factors including vascular and osteoinductive factors and could stimulate bone regeneration.
              - Two-stage reconstruction of post-traumatic segmental tibia bone loss with nailing.
              - Reamer-irrigator-aspirator bone graft and bi Masquelet technique for segmental bone defect nonunions: a review of 25 cases.
              - Masquelet technique for the treatment of a severe acute tibial bone loss.
              - Treatment of posttraumatic bone defects by the induced membrane technique.  
              - Reconstruction of Long Bone Infections Using the Induced Membrane Technique: Tips and Tricks.
              - Treatment of Bone Loss With the Induced Membrane Technique: Techniques and Outcomes.
              - Membrane Induced Osteogenesis in the Management of Post-traumatic Bone Defects
              - Reconstruction of an extensive soft tissue and bone defect of the first metatarsal with the use of Masquelet technique: a case report.