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Telangiectatic Osteosarcoma

- Discussion:
    - an uncommon type of osteosarcoma w/ early pulmonary metastasis & an especially poor prognosis;
    - telangiectatic osteosarcoma has a complex karyotypes with multiple chromosomal abnormalities.

- Differential Dx:
     - Aneurysmal bone cyst;
           - this is both radiographically and pathologically similar to telangectatic osteosarcoma;
           - unlike osteosarcoma, ABCs appear to be karyotypically normal;

- Histology:
    - characterized by loose sarcomatous stroma w/ septa and spaces along w/ ectatic blood vessels (similar to ABC);
    - high anaplastic tumor cells, malignant giant cells & pathologic mitotic figures;
    - osteoid production may be minimal;

- Radiographs:
    - highly destructive lesion

Telangiectatic osteogenic sarcoma of the extremities. Results in 17 patients treated with neoadjuvant chemotherapy.

Telangiectatic osteosarcoma.

Osteosarcoma with small cells simulating Ewing's tumor.