- Discussion:
    - tissue mineralization is considered to be last step in bone formation;
    - principal mineral salt of bone exists primarily in form of crystalline hydroxyapatite, which is thermodynamically stable phase at normal 
         tissue pH;
    - first step in the precipitation of bone salts must involve some type of nucleation, that is, the formation of a mineral arrangement of calcium 
         and phosphate ions capable of crystal growth;
    - phenomenon of nucleation of "seeding" is explained by the concept of undersaturation of body fluids with calcium and phosphate until the
         first precipitate is formed