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- Treatment of Hyperosmolar Non Ketotic Coma: 
- Infusion of Normal Saline to restore volume 
- Reg Insulin 10-25 units IV 
- Insulin drip 5-10 units/hr until Serum Glucose < 500 mg/dl; 
- Insulin given IV has plasma t 1/2 of 5 min and a biologic effect for about 20 min; 
- thus, even brief period of insulin deficiency, esp in patient w/ IDDM, may allow rapid deterioration in metabolic control