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Fresh Frozen Plasma

 


- See: 
       - warfarin
       - coags 
       - transfusion therapy 

 - Volume: Approximately 200mL;
 - Dose: 2 units FFP
 - Maximum admistration time: 4 hrs;
 - Rate of infusion: depends on patient's clinical condition;
 - Indications: Bleeding w/ labile Coagulation factor deficiencies; (Factor V or VIII)
 - Note: Must allow 20-30min to thaw;
 - FFP contains all clotting factors including the labile factors V and VIII as well as 250 to 400 mg of Fibrinogen;
 - FFP contains anti-erythrocyte antibodies, & is given type specific product;
 - after every 6 units of blood is given, two units of FFP is given, and after every ten units of blood, six units of platelets should be infused;
 - effectiveness of FFP will lapse within hours, requiring administration;
 - FFP has been associatted with non cardiac pulmonary edema;
 - one should not administer FFP to correct clotting studies unless the patient shows excess bleeding 


- Effect of fresh-frozen plasma resuscitation on cardiopulmonary function and serum protein flux.

Fresh frozen plasma supplement to massive red blood cell transfusion.

Evolution of a multidisciplinary clinical pathway for the management of unstable patients with pelvic fractures.

- Fresh frozen plasma should be given earlier to patients requiring massive transfusion.