- Discussion:
- for preoperative sedation; impairment of memory of perioperative events;
- sedation for procedures, short acting benzodiazepine:
- versed is 3 to 4 times more powerful per mg. than valium
- may dilute injection in D5W, NS, or LR;
- Conscious Sedation:
- Dose: 0.1-0.2 mg/kg/dose IM/IV; 1.0 mg/kg/dose PR;
- Adult: Sedation: 0.07-.08mg/kg/dose IM 15min-1hr. prior to procedure;
or: 0.035mg/kg/dose repeated as prn; max: 0.2mg/kg/ total;
- 1 mg/ml IV, no more than 2.5 mg should be given over a period of 2 min;
- wait another 2 min. to evaluate sedative effects;
- a total dose of greater than 5 mg is not usually necessary;
- decrease the dose in the elderly;
- Peds: Bolus:
- 0.05-0.3 mg/kg IV q1-2 hrs;
- children may be more resistant to versed and have faster elimination than adults;
- Gen Anesthesia:
- 0.3-0.5mg/kg IV, then incr in increments by .07-.09mg/kg up to a total of 0.6mg/kg to induce anesthesia; Monitor respiration;
- IM: Onset: at 15 min; Peak at 30-60 min.
- IV: sedative effects: at 3-5 min; duration: 20-30 min;
- Midazolam is well-absorbed PO and IM; onset of anesthesia following IV administration occurs 1 to 1.5 minutes, slower than thiopental but faster than diazepam;
the drug is metabolized in the liver and excreted in the urine (0.3% unchanged);
the elimination half-life is 2 to 5 hours;
midazolam is highly protein-bound (95%).