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Zyvox / Linezolid

- See: Zyvox Commercial Web Site

- Discussion:
- for MRSA and staph epi infections;
- dose: 600 mg PO bid;
- in standard dosing, the plasma and tissue levels will be between 10-11 mcg/ml (about 4 mcg/ml in bone);
- mao inhibitors
          - linezolid is a reversible, nonselective inhibitor of monoamine oxidase;
- linezolid has the potential for interaction with adrenergic and serotonergic agents;
    - side effects include myelo - suppression, peripheral neuropathy, and optic nerve issues;


- References:
- Successful treatment of chronic bone and joint infections with oral linezolid.

- Linezolid in the Treatment of Implant-related Chronic Osteomyelitis.

- Linezolid treatment of prosthetic hip Infections due to methicillin-resistant Staphylococcus aureus (MRSA).

- Safety and tolerability of linezolid.

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