Home » Ortho Related » Medications » TRAZODONE/DESYREL TRAZODONE/DESYREL major depression; Adult:150mg PO qd initially, increase 50mg/day q3-4 day; maximum:400 upto 600 mg/day; may take 1-2 weeks for effect; Note Side Effects: Sedation: +++;Insomnia: 0; Anticholinergic: 0; Orthostatic Hypotension: +++; Nausea: 0